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Observe Intently (1)mitotane decreases levels of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Mitotane is a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for doable dosage changes.It is important to note that Bizarro K2 is unlawful in many countries and it